Update on the genetics of age-related macular degeneration

被引：2
|
作者：
Fajnkuchen, F. [1 ,2 ]
Cohen, S. Y. [1 ,3 ]
机构：
[1] Ctr Ophtalmol Imagerie & Laser, F-75015 Paris, France
[2] Hop Avicenne, AP HP, Serv Ophtalmol, F-93009 Bobigny, France
[3] Hop Lariboisiere, AP HP, Serv Ophtalmol, F-75475 Paris, France
来源：
JOURNAL FRANCAIS D OPHTALMOLOGIE | 2008年 / 31卷 / 06期
关键词：
age-related macular degeneration; LOC; 387715/HTRA1; CFH; C2-FB;
D O I：
10.1016/S0181-5512(08)75469-X
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The relationship between genetics and age-related macular degeneration is well established. Heritability has been estimated to be up to 70%. Recent studies have identified several chromosomal regions that are likely to contain susceptibility loci. Common variations in three genes (CFH, LOC 387715 and C2413) strongly influence the risk of age-related macular degeneration. New findings in the field of the genetics of age-related macular degeneration are a starting point toward understanding the causes of AMD and for future therapeutic studies.
引用
收藏
页码：630 / 637
页数：8
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