Modulation of the Gut Microbiome to Enhance Immunotherapy Response in Metastatic Melanoma Patients: A Clinical Review

被引：9
|
作者：
Najmi, Maleka [1 ]
Tran, Tiffaney [2 ]
Witt, Russell G. [3 ]
Nelson, Kelly C. [4 ]
机构：
[1] Baylor Scott & White Med Ctr, Dept Internal Med, 2401 S 31st St MS 01-161B, Temple, TX 76508 USA
[2] Baylor Coll Med, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Dermatol, Houston, TX 77030 USA
来源：
DERMATOLOGY AND THERAPY | 2022年 / 12卷 / 11期
基金：
美国国家卫生研究院;
关键词：
Gut microbiome; Fecal microbiota transplantation; Immunotherapy; Anti-CTLA-4; Anti-PD-1; Metastatic melanoma; Advanced melanoma; CANCER; BACTERIOTHERAPY; MANAGEMENT; PROBIOTICS; EFFICACY; IMMUNITY; THERAPY;
D O I：
10.1007/s13555-022-00810-1
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
For patients with metastatic melanoma, immunotherapy agents represent a promising treatment option, and researchers are actively seeking to identify factors that may predict a favorable response in patients. Recent studies have elucidated possible associations between the gut microbiome and the effects of immunotherapy, where variations in the gut microbiome may influence treatment response and frequency of adverse effects. In this clinical review, we describe the current literature related to the gut microbiome in the setting of immunotherapy, and we provide an overview of interventions under investigation that may modulate the gut microbiome. These interventions include fecal microbiota transplantation, probiotics, and dietary modifications.
引用
收藏
页码：2489 / 2497
页数：9
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