Capturing circulating tumor cells of hepatocellular carcinoma

被引：53

作者：

Wu, Li-Jun ^{[2
]}

Pan, Yi-Da ^{[2
]}

Pei, Xiao-Yu ^{[2
]}

Chen, Hong ^{[3
]}

Nguyen, Samantha ^{[4
]}

Kashyap, Akshay ^{[4
]}

Liu, Jie ^{[1
,2
]}

Wu, Jian ^{[2
,4
,5
]}

机构：

[1] Fudan Univ, Huashan Hosp, Inst Digest Dis, Dept Digest Dis, Shanghai 210040, Peoples R China

[2] Fudan Univ, Inst Digest Dis, Shanghai 210040, Peoples R China

[3] Southeast Univ, Coll Med, Dept Gastroenterol & Hepatol, Nanjing 210009, Jiangsu, Peoples R China

[4] Univ Calif Davis, Med Ctr, Dept Internal Med, Div Gastroenterol & Hepatol, Sacramento, CA 95817 USA

[5] Univ Calif Davis, Ctr Comprehens Canc, Sacramento, CA 95817 USA

来源：

CANCER LETTERS | 2012年 / 326卷 / 01期

关键词：

Circulating tumor cells; Hepatocellular carcinoma; Cancer stem cells; Tumor self-seeding; HCC thrombus formation in the portal vein; CANCER STEM-CELLS; LIVER-TRANSPLANTATION; IDENTIFICATION; BLOOD; METASTASIS; RECURRENCE; EXPRESSION; SIZE;

D O I：

10.1016/j.canlet.2012.07.024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Early metastases of hepatocellular carcinoma (HCC) may be detected by the isolation of circulating tumor cells (CTCs) in the bloodstream. During the course of therapeutic attempts, monitoring CTC changes in patients with HCC is helpful for the efficacy assessment. Nevertheless, the markers used for the detection, such as alpha-feto protein, asialoglycoprotein receptor or epithelial cell adhesion molecule, CD133 or CD90, are not specific for HCC CTCs. In spite of these limitations, a timely determination of the existence of CTCs will be beneficial for the monitoring of distant metastases, the evaluation of therapeutic attempts, and the prediction of prognosis. (C) 2012 Elsevier Ireland Ltd. All rights reserved.

引用

页码：17 / 22

页数：6

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