Synthesis of novel cationic poly(ethylene glycol) containing lipids

被引：31
|
作者：
Schulze, U
Schmidt, HW
Safinya, CR
机构：
[1] Univ Bayreuth, Bayreuther Inst Makromol Forsch, D-95440 Bayreuth, Germany
[2] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA
[3] Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA
[4] Univ Calif Santa Barbara, Biochem & Mol Biol Program, Santa Barbara, CA 93106 USA
来源：
BIOCONJUGATE CHEMISTRY | 1999年 / 10卷 / 03期
关键词：
D O I：
10.1021/bc9801068
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
degrees In this paper, the synthesis of novel divalent cationic lipids with poly(ethylene glycol) segments is described. The lipids consist of an unsaturated double-chain hydrophobic moiety based on 3,4-dihydroxy benzoic acid, attached to a hydrophilic poly(ethylene glycol) spacer which contains a divalent cationic end group. As poly(ethylene glycol) spacers monodisperse triethylene glycol and telechelic poly(ethylene glycol)s with an average degree of polymerization of 9, 23, and 45 were used. The divalent cationic end group was attached by coupling a protected dibasic amino acid to the PEG spacer and following cleavage of the protecting groups. These novel class of cationic lipids is of particular interest for nonviral gene delivery applications.
引用
收藏
页码：548 / 552
页数：5
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