Quantification of dopamine D1 and D2 receptor mRNA levels associated with the development of behavioral sensitization in amphetamine treated rats

被引：13
|
作者：
Richtand, NM
Kelsoe, JR
Kuczenski, R
Segal, DS
机构：
[1] SAN DIEGO VET AFFAIRS MED CTR,DEPT PSYCHIAT,LA JOLLA,CA 92161
[2] UNIV CALIF SAN DIEGO,DEPT PSYCHIAT,LA JOLLA,CA 92093
来源：
NEUROCHEMISTRY INTERNATIONAL | 1997年 / 31卷 / 01期
关键词：
D O I：
10.1016/S0197-0186(96)00097-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We hypothesized that changes in expression of dopamine (DA) D1 and D2 receptor genes in caudate/putamen (CP) would correlate with the development of behavioral changes in amphetamine treated rats. In order to test this hypothesis, we measured DA D1 and D2 receptor mRNA in CP, as well as locomotor behavior, in individual rats following amphetamine treatment. D1 and D2 mRNA levels were similar in caudate/putamen of rats treated with acute amphetamine, chronic amphetamine or saline injection. We found no correlation between D1 or D2 mRNA levels in caudate/putamen and the behavioral response to either acute or chronic amphetamine. These results suggest that behavioral sensitization to amphetamine is not mediated through transcriptional regulation of D1 or D2 mRNA levels in caudate/putamen. Published by Elsevier Science Ltd.
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页码：131 / 137
页数：7
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