Association between the SPRY1 gene polymorphism and obesity-related traits and osteoporosis in Korean women

Background: Emerging evidence has revealed a close relationship between obesity and osteoporosis. It was reported recently that conditional knockout of the Spry) gene in mice adipocytes causes an increase in body fat and a decrease in bone mass, and that these phenotypes are rescued by Spry) overexpression in adipose tissue. In this study, we investigated whether genetic variation in the human SPRY) gene is associated with obesity-related phenotypes and/or osteoporosis in humans. Methods: We performed a candidate gene association analysis between the four single nucleotide polymorphisms (SNPs) and 14 imputed SNPs in the SPRY) gene and obesity-related traits and osteoporosis in a Korean women cohort (3013 subjects). Results: All four SPRY) gene SNPs were significantly associated with either obesity-related traits or osteoporosis. The TGCC haplotype in the SRPY1 gene showed simultaneous association with an increased risk for obesity-related traits, percentage body fat (p=0.0087) and percentage abdominal fat (p=0.047), and osteoporosis (odds ratio=1.50; p=0.025) in the recessive genetic model. Conclusions: Our results support a previous finding in conditional Spry) gene knockout mice and suggest that the SPRY) gene is an important genetic factor for determining the risk of both obesity and osteoporosis in humans. (C) 2012 Elsevier Inc. All rights reserved.