Anti-AIDS agents. Part 36: 17-carboxylated steroids as potential anti-HIV agents

被引：13
|
作者：
Xia, P
Yang, ZY
Xia, Y
Zheng, YQ
Cosentino, LM
Lee, KH [1 ]
机构：
[1] Univ N Carolina, Sch Pharm, Div Med Chem & Nat Prod, Nat Prod Lab, Chapel Hill, NC 27599 USA
[2] Shanghai Med Univ, Dept Organ Chem, Sch Pharm, Shanghai 200032, Peoples R China
[3] Biotech Res Labs Inc, Gaithersburg, MD 20877 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 1999年 / 7卷 / 09期
关键词：
anti-HIV; 17-carboxylated steroid;
D O I：
10.1016/S0968-0896(99)00169-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In our search for novel anti-HIV agents, seven 17-carboxylated steroid derivatives were synthesized and evaluated as potential anti-HIV agents. Compound 13 exhibited potent anti-HIV activity in acutely infected H9 lymphocytes with EC50 and therapeutic index values of 0.8 mu M and 300, respectively. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：1907 / 1911
页数：5
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