Bioinspired Hydrogels for 3D Organoid Culture

被引：50
|
作者：
Blondel, Delphine [1 ,2 ]
Lutolf, Matthias P. [1 ,2 ,3 ]
机构：
[1] Ecole Polytech Fed Lausanne, Sch Life Sci, Inst Bioengn, Lab Stem Cell Bioengn, CH-1015 Lausanne, Switzerland
[2] Ecole Polytech Fed Lausanne, Sch Engn, CH-1015 Lausanne, Switzerland
[3] Ecole Polytech Fed Lausanne, Sch Basic Sci, Inst Chem Sci & Engn, CH-1015 Lausanne, Switzerland
来源：
CHIMIA | 2019年 / 73卷 / 1-2期
关键词：
ECM; Hydrogel; Matrigel (TM); Organoid; Photo-patterning; Synthetic gel; Self-healing; INTESTINAL STEM-CELL; MORPHOGENESIS; MATRIX;
D O I：
10.2533/chimia.2019.81
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Organoids have stepped into the limelight as unique in vitro systems for modeling organ development, function and disease. This review provides a perspective on how chemically defined, bio-inspired hydrogels could be used for replacing ill-defined matrices derived from the native extracellular matrix (ECM) that are used for generating organoids in 3D stem cell culture. In particular, we propose the use of self-healing and light-responsive matrices that should afford control over the inherently stochastic self-organization process that currently underlies organoid morphogenesis. Such designer ECMs could accelerate the translation of organoid technology from the laboratory into various real-life applications.
引用
收藏
页码：81 / 85
页数：5
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