P(NMe2)3-mediated reductive [1+4] annulation of isatins with enones: a facile synthesis of spirooxindole-dihydrofurans

被引：61
|
作者：
Zhou, Rong [1 ]
Zhang, Kai [1 ]
Chen, Yusong [1 ]
Meng, Qiang [1 ]
Liu, Yiyi [2 ]
Li, Ruifeng [1 ]
He, Zhengjie [2 ,3 ]
机构：
[1] Taiyuan Univ Technol, Coll Chem & Chem Engn, Taiyuan 030024, Peoples R China
[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
[3] Nankai Univ, Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300071, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 78期
基金：
中国国家自然科学基金;
关键词：
CATALYTIC ASYMMETRIC-SYNTHESIS; ALPHA-KETO ESTERS; DIASTEREOSELECTIVE SYNTHESIS; SPIROCYCLIC OXINDOLES; CONSTRUCTION; CONDENSATION; DERIVATIVES; CYCLOADDITION; DIKETONES; ALKALOIDS;
D O I：
10.1039/c5cc03676c
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A novel P(NMe2)(3)-mediated reductive [1+4] annulation reaction between isatins and enones has been developed, providing the facile synthesis of spirooxindole-dihydrofurans. This reaction unveils the first practical approach to construct five-membered cyclic motifs via a Kukhtin-Ramirez adduct involved [1+4] annulation mode.
引用
收藏
页码：14663 / 14666
页数：4
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