Cytotoxic steroidal saponins from Ophiopogon japonicus

被引：49
|
作者：
Li, Ning [1 ]
Zhang, Liang [1 ]
Zeng, Ke-Wu [1 ]
Zhou, Yuan [1 ]
Zhang, Jia-Yu [1 ]
Che, Yan-Yun [1 ]
Tu, Peng-Fei [1 ]
机构：
[1] Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
来源：
STEROIDS | 2013年 / 78卷 / 01期
关键词：
Ophiopogon japonicus; Steroidal saponins; Cytotoxic activity; GLYCOSIDES; TUBERS;
D O I：
10.1016/j.steroids.2012.10.001
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Four new steroidal saponins, named ophiopogonin P-S (1-4), together with eleven known ones (5-15) were isolated from the tuberous roots of Ophiopogon japonicus. Their structures were elucidated by spectroscopic and chemical analysis. Compounds 2-15 were evaluated for their cytotoxic activity against five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela). Compounds 2, 5, 6, 8 and 9 were cytotoxic for all cell lines tested. Compounds 7, 11 and 15 showed selective cytotoxicity against some of the cell lines. The structure-activity relationship of these compounds was discussed. (C) 2012 Elsevier Inc. All rights reserved.
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页码：1 / 7
页数：7
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