DNA methylation-based classification and identification of bladder cancer prognosis-associated subgroups

被引:11
|
作者
Tian, Zijian [1 ,2 ]
Meng, Lingfeng [1 ,2 ]
Long, Xingbo [1 ]
Diao, Tongxiang [1 ]
Hu, Maolin [1 ]
Wang, Miao [1 ]
Liu, Ming [1 ]
Wang, Jianye [1 ,2 ]
机构
[1] Chinese Acad Med Sci, Inst Geriatr Med, Natl Ctr Gerontol, Dept Urol,Beijing Hosp, 1 DaHua Rd, Beijing 100730, Peoples R China
[2] Chinese Acad Med Sci, Peking Union Med Coll, Grad Sch, 9 DongDan SANTIAO, Beijing 100730, Peoples R China
关键词
DNA Methylation; Urinary bladder neoplasms; Epigenetics; Cluster analysis; UROTHELIAL CARCINOMA; BIOMARKERS; EPIGENOME;
D O I
10.1186/s12935-020-01345-1
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
BackgroundBladder cancer (BCA) is the most common urinary tumor, but its pathogenesis is unclear, and the associated treatment strategy has rarely been updated. In recent years, a deeper understanding of tumor epigenetics has been gained, providing new opportunities for cancer detection and treatment.MethodsWe identified prognostic methylation sites based on DNA methylation profiles of BCA in the TCGA database and constructed a specific prognostic subgroup.ResultsBased on the consistent clustering of 402 CpGs, we identified seven subgroups that had a significant association with survival. The difference in DNA methylation levels was related to T stage, N stage, M stage, grade, sex, age, stage and prognosis. Finally, the prediction model was constructed using a Cox regression model and verified using the test dataset; the prognosis was consistent with that of the training set.ConclusionsThe classification based on DNA methylation is closely related to the clinicopathological characteristics of BCA and determines the prognostic value of each epigenetic subtype. Therefore, our findings provide a basis for the development of DNA methylation subtype-specific therapeutic strategies for human bladder cancer.
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页数:11
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