Regioselective [3+2] Cycloaddition Reaction of 3-Alkynoates with Seyferth-Gilbert Reagent

被引：8
|
作者：
Tian, Yu-Ting [1 ,2 ,3 ]
Zhang, Fa-Guang [1 ,2 ,3 ]
Ma, Jun-An [1 ,2 ,3 ]
机构：
[1] Tianjin Univ, Minist Educ, Frontiers Sci Ctr Synthet Biol, Dept Chem,Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Tianjin Collaborat Innovat Ctr Chem Sci & Engn, Tianjin 300072, Peoples R China
[3] Tianjin Univ, Joint Sch Natl Univ Singapore & Tianjin Univ, Int Campus, Fuzhou 350207, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 04期
基金：
中国国家自然科学基金;
关键词：
BESTMANN-OHIRA REAGENT; ACCESS; HETEROCYCLES; ALKYNOATES; PHOSPHONYL; ANNULATION; ALDEHYDES; ESTERS;
D O I：
10.1021/acs.joc.0c02957
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Et3N-triggered regioselective [3 + 2] cyclo-addition reaction of 3-alkynoates with Seyferth-Gilbert reagent has been developed to furnish a series of trisubstituted pyrazole-3-phosphonates. A one-pot cycloaddition/alkylation sequence further offered access to the corresponding fully substituted pyrazoles.
引用
收藏
页码：3574 / 3582
页数：9
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