Surface Modification of Magnetic Fe3O4 Nanoparticles by Folic Acid

Amine-functionalized magnetite Fe3O4 nanoparticles were synthesized by a facile one-pot template-free solvothermal method via using FeCl3 center dot 6H(2)O as a single iron source, 1,6-hexanediamine as a reagent providing amine, and magnetite Fe3O4 composite nanoparticles with folic acid (FA) molecules were synthesized by bonding of the amine-functionalized magnetite nanoparticles with folic acid molecules. The morphology, size, chemical component and magnetic property of as-prepared composite nanoparticles were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction, transmission electron microscopy (TEM), thermogravimetry-differential scanning calorimeter (TG-DSC) and vibrating sample magnetometer (VSM). The results show that folic acid (FA) molecules are conjugated on the surface of magnetic Fe3O4 nanoparticles, and the composite nanoparticles have still good magnetic property after surface modification by folic acid.