BRCA1 and Oxidative Stress

被引：44

作者：

Yi, Yong ^{[1
]}

Kang, Hyo ^{[1
]}

Bae, Insoo ^{[1
,2
]}

机构：

[1] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Dept Oncol, Washington, DC 20057 USA

[2] Georgetown Univ, Med Ctr, Lombardi Comprehens Canc Ctr, Dept Radiat Med, Washington, DC 20057 USA

来源：

CANCERS | 2014年 / 6卷 / 02期

关键词：

BRCA; oxidative stress; reactive oxygen species (ROS); carcinogenesis; detoxification; DNA-DAMAGE-RESPONSE; INDUCIBLE GENE-EXPRESSION; ESTROGEN-RECEPTOR-ALPHA; TUMOR-SUPPRESSOR BRCA1; INTERACT IN-VIVO; BREAST-CANCER; CELL-CYCLE; TRANSCRIPTIONAL REGULATION; OVARIAN-CANCER; REDOX REGULATION;

D O I：

10.3390/cancers6020771

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The breast cancer susceptibility gene 1 (BRCA1) has been well established as a tumor suppressor and functions primarily by maintaining genome integrity. Genome stability is compromised when cells are exposed to oxidative stress. Increasing evidence suggests that BRCA1 regulates oxidative stress and this may be another mechanism in preventing carcinogenesis in normal cells. Oxidative stress caused by reactive oxygen species (ROS) is implicated in carcinogenesis and is used strategically to treat human cancer. Thus, it is essential to understand the function of BRCA1 in oxidative stress regulation. In this review, we briefly summarize BRCA1' s many binding partners and mechanisms, and discuss data supporting the function of BRCA1 in oxidative stress regulation. Finally, we consider its significance in prevention and/or treatment of BRCA1-related cancers.

引用

页码：771 / 795

页数：25

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