Two New Flavones from Salvia plebeia and Their Anti-Angiogenic Activities

被引：0
|
作者：
Ma, Qinge [1 ]
Wei, Rongrui [1 ]
Lu, Qixin [1 ]
Huang, Haofeng [1 ]
Guo, Dongmei [1 ]
Jiang, Lin [1 ]
机构：
[1] Jiangxi Univ Tradit Chinese Med, Res Ctr Nat Resources Chinese Med Mat & Ethn Med, Key Lab Modern Preparat TCM, Minist Educ, Nanchang 330004, Jiangxi, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2020年 / 56卷 / 06期
关键词：
Salvia plebeia; flavone; anti-angiogenic activity; SESQUITERPENOIDS; DERIVATIVES;
D O I：
10.1007/s10600-020-03218-5
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new flavones, namely 5-hydroxy-2-(4 '-hydroxyphenyl)-6,12,13-trimethoxypyrano-xanthene-4,9-dione (1) and 5-hydroxy-2-(3 '-methoxy-4 '-hydroxyphenyl)-6-methoxy-11-isopropyl-pyranochromene-4,9-dione (2), were isolated from Salvia plebeia. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR spectral data. Compounds 1 and 2 were evaluated for their anti-angiogenic activities by the MTT assay with axitinib as positive control, and they displayed moderate anti-angiogenic activities with IC50 values of 14.07 and 11.25 mu M, respectively.
引用
收藏
页码：1019 / 1022
页数：4
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