The reasons of Trithorax-like expression disturbance in Trl 3609 allele of Drosophila melanogaster

被引：3

作者：

Karagodin, D. A. ^{[1
]}

Battulina, N. V. ^{[1
]}

Merkulova, T. I. ^{[1
]}

Baricheva, E. M. ^{[1
]}

机构：

[1] Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia

来源：

DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2016年 / 471卷 / 01期

关键词：

GAGA FACTOR; GENE; ENCODES;

D O I：

10.1134/S1607672916060181

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The regulatory region of the Trl gene was analyzed using the mutation Trl (3609) , resulting from the insertion of the P-element into the promoter region of the gene as well as mutations obtained on its basis. It is shown that two last transcription start sites, which are most often used in vitro in S2 cells, are almost not used in vivo. Experimental data indicate that transcription terminators in transposons play an important role in the decrease in the transcription level of the recipient gene.

引用

页码：443 / 446

页数：4

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