The structural basis for specific decoding of AUA by isoleucine tRNA on the ribosome

被引：35
|
作者：
Voorhees, Rebecca M. [1 ]
Mandal, Debabrata [2 ]
Neubauer, Cajetan [1 ]
Koehrer, Caroline [2 ]
RajBhandary, Uttam L. [2 ]
Ramakrishnan, V. [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2013年 / 20卷 / 05期
基金：
英国医学研究理事会; 英国惠康基金; 美国国家卫生研究院;
关键词：
AMINO-ACID SPECIFICITIES; MODIFIED NUCLEOSIDES; WOBBLE HYPOTHESIS; CODON; ANTICODON; RECOGNITION; CYTIDINE; POSITION; SYSTEM;
D O I：
10.1038/nsmb.2545
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Decoding of the AUA isoleucine codon in bacteria and archaea requires modification of a C in the anticodon wobble position of the isoleucine tRNA. Here, we report the crystal structure of the archaeal tRNA(2)(Ile), which contains the modification agmatidine in its anticodon, in complex with the AUA codon on the 70S ribosome. The structure illustrates how agmatidine confers codon specificity for AUA over AUG.
引用
收藏
页码：641 / +
页数：4
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