Cu(OTf)2-Catalyzed Intramolecular Radical Cascade Reactions for the Diversity-Oriented Synthesis of Quinoline-Annulated Polyheterocyclic Frameworks

被引：19

作者：

Yuan, Shuo ^{[1
]}

Zhang, Jingya ^{[1
]}

Zhang, Danqing ^{[1
]}

Wei, Donghui ^{[2
,3
]}

Zuo, Jiahui ^{[1
]}

Song, Jian ^{[1
]}

Yu, Bin ^{[1
]}

Liu, Hong-Min ^{[1
]}

机构：

[1] Zhengzhou Univ, Sch Pharmaceut Sci, Zhengzhou 450001, Peoples R China

[2] Zhengzhou Univ, Coll Chem, Zhengzhou 450001, Peoples R China

[3] Zhengzhou Univ, Inst Green Catalysis, Zhengzhou 450001, Peoples R China

来源：

ORGANIC LETTERS | 2021年 / 23卷 / 04期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

D O I：

10.1021/acs.orglett.1c00129

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Compound libraries with high levels of structural diversity and novelty could cover underexploited chemical space and thus have been highly pursued in drug discovery. Herein, we report the first Cu(OTf)(2)-catalyzed intramolecular radical cascade reactions that enable the diversity-oriented synthesis of quinoline-annulated polyheterocyclic compounds (7 unique scaffolds, 66 examples) in an efficient manner. This work demonstrates an alternative route to access the natural product- and druglike compound collection with high levels of structural diversity and novelty.

引用

页码：1445 / 1450

页数：6

共 9 条

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SYNLETT, 2018, 29 (12) : 1552 - 1571
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