Global Stability for a Mathematical Model of Hepatitis C: Impact of a Possible Vaccination with DAAs Therapy

被引：2
|
作者：
Lombardo, Salvo Danilo [1 ]
Lombardo, Sebastiano [2 ]
机构：
[1] Univ Catania, Dept Biomed & Biotechnol Sci, I-95123 Catania, Italy
[2] Univ Catania, Dept Math & Comp Sci, I-95125 Catania, Italy
来源：
SIXTH INTERNATIONAL CONFERENCE NEW TRENDS IN THE APPLICATIONS OF DIFFERENTIAL EQUATIONS IN SCIENCES (NTADES 2019) | 2019年 / 2159卷
关键词：
D O I：
10.1063/1.5127485
中图分类号：
O29 [应用数学];
学科分类号：
070104 ;
摘要：
Direct anti-viral agents (DAAs) allow to obtain the eradication of hepatitis C virus, but they do not prevent from possible re-infections. A vaccine can be useful to achieve this goal. Here, we study the global asymptotical stability (GAS) of the infection-free equilibrium for a recent model of hepatitis C, including immune response and alanine-aminotransferase production. Some sufficient conditions of global stability, based on the existence of a minimum positive antibody value, are obtained, thus confirming the importance of a post-therapy vaccine as an effective preventive defense to subsequent viral attacks.
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页数：7
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