Speciation analysis with hyphenated technique of high performance liquid chromatography and inductively coupled plasma mass spectrometry

This paper mainly describes the development of speciation analysis in environmental, material and life scientific samples by the hyphenated technique of high performance liquid chromatography and inductively coupled plasma mass spectrometry (HPLC-ICP-MS). The emphasis is made on the interface between separation technique and ICP-MS as well as the main types of the liquid chromatography. Some methods of sample pretreatment are elucidated. In addition, the problems related to the speciation analysis by HPLC-ICP-MS, such as the sample introducing systems, the matrix separation and the speciation analysis of qualitative identification and quantification are briefly discussed.