Human Immunodeficiency Virus/AIDS, Human Papillomavirus, and Anal Cancer

被引：54

作者：

Wang, Chia-ching J. ^{[1
]}

Sparano, Joseph ^{[2
]}

Palefsky, Joel M. ^{[3
]}

机构：

[1] Zuckerberg San Francisco Gen Hosp, Div Hematol Oncol, Dept Med, 995 Potrero Ave,Bldg 80,4th Floor, San Francisco, CA 94110 USA

[2] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Oncol, 1695 Eastchester Rd, Bronx, NY 10461 USA

[3] Univ Calif San Francisco, Div Infect Dis, Dept Med, 513 Parnassus Ave,Med Sci Room 420E,Box 0654, San Francisco, CA 94143 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2017年 / 26卷 / 01期

关键词：

HPV; HPV vaccination; Anal cancer; HIV; Immunosuppression; SQUAMOUS-CELL CARCINOMA; ACTIVE ANTIRETROVIRAL THERAPY; HIV-POSITIVE PATIENTS; INTRAEPITHELIAL NEOPLASIA; INFECTED PATIENTS; HPV VACCINE; TREATMENT TOLERANCE; PLUS CETUXIMAB; UNITED-STATES; T-CELLS;

D O I：

10.1016/j.soc.2016.07.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Anal cancer is an increasingly common non AIDS-defining cancer among individuals infected with the human immunodeficiency virus (HIV). It is associated with human papillomavirus (HPV). HPV16 is the most common genotype detected in anal cancers. The HPV types detected in anal cancer are included in the 9-valent vaccine. HPV vaccines have demonstrated efficacy in reducing anal precancerous lesions in HIV-infected individuals. Standard treatment has been fluorouracil and mitomycin (or cisplatin) plus radiation. Continued studies are needed to test new treatment strategies in HIV-infected patients with anal cancer to determine which treatment protocols provide the best therapeutic index.

引用

页码：17 / +

页数：16

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