Hemostatic, Antibacterial and Degradable Performance of the Water-soluble Chitosan-coated Oxidized Regenerated Cellulose Gauze

被引：27
|
作者：
He, Jin Mei [1 ]
Wu, Ya Dong [1 ]
Wang, Feng Wen [1 ]
Cheng, Wei Lu [1 ]
Huang, Yu Dong [1 ]
Fu, Bo [2 ]
机构：
[1] Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Sch Chem Engn & Technol, Harbin 150001, Peoples R China
[2] WeGo Grp Co Ltd, Weihai 264209, Peoples R China
来源：
FIBERS AND POLYMERS | 2014年 / 15卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Oxidized regenerated cellulose; Chitosan; Water-soluble; Hemostatic; Degradable;
D O I：
10.1007/s12221-014-0504-5
中图分类号：
TB3 [工程材料学]; TS1 [纺织工业、染整工业];
学科分类号：
0805 ; 080502 ; 0821 ;
摘要：
In this research, the oxidized regenerated cellulose (ORC) gauze was prepared by oxidation of regenerated cellulose using NO2/CCl4, subsequently treated with the dissolved chitosan (CTS) in aqueous acetic acid (CTS/ORC) and finally neutralized with NaOH/C2H5OH (CTS/ORC-Na). The hemostatic, antibacterial and degradable properties of treated ORC-based gauze were evaluated. The results of the hemostatic test on rabbit liver and ear-artery injuries showed that the attachment of high molecular weight chitosan to the surface of ORC gauze significantly improved the hemostatic effect of ORC without compromising the antibacterial and degradability of ORC. It is found that the water-soluble CTS/ORC-Na gauze was more suitable as the hemostatic material applied in rabbit liver injury in comparison with in ear-artery injury and it further improved the hemostatic efficacy and enhanced the degradable rate. It is promised that the CTS/ORC gauze and the water-soluble CTS/ORC-Na gauze would be applicable in medical fields such as surgical absorbable hemostats for control bleeding.
引用
收藏
页码：504 / 509
页数：6
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