Heterogeneous Resistance Mechanisms in Rebiopsies from EGFR-Mutated NSCLC: Transformation to SCLC; FGFR3 and T790M Mutations

被引:0
|
作者
Urbanska, E. [1 ]
Grauslund, M. [2 ]
Melchior, L. [3 ]
Sorensen, J. B. [1 ]
Santoni-Rugiu, E. [1 ]
机构
[1] Univ Copenhagen, Dept Oncol, Finsens Ctr, Rigshosp, Copenhagen, Denmark
[2] Skane Univ Hosp, Dept Pathol, Lund, Sweden
[3] Univ Copenhagen, Dept Pathol, Finsens Ctr, Rigshosp, Copenhagen, Denmark
关键词
D O I
10.1016/j.jtho.2017.09.1449
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P3.01-007
引用
收藏
页码:S2203 / S2203
页数:1
相关论文
共 50 条
  • [1] Incidence of T790M mutation in (sequential) rebiopsies in EGFR-mutated NSCLC-patients
    Kuiper, J. L.
    Heideman, D. A. M.
    Thunnissen, E.
    Paul, M. A.
    van Wijk, A. W.
    Postmus, P. E.
    Smit, E. F.
    LUNG CANCER, 2014, 85 (01) : 19 - 24
  • [2] RETROSPECTIVE ANALYSIS OF REBIOPSIES IN A COHORT OF EGFR-MUTATED NSCLC-PATIENTS WITH TKI-RESISTANCE; INCIDENCE OF THE T790M MUTATION.
    Kuiper, Justine L.
    Thunnissen, Erik
    Heideman, Danielle A. M.
    Paul, Marinus A.
    Smit, Egbert F.
    JOURNAL OF THORACIC ONCOLOGY, 2013, 8 : S1083 - S1084
  • [3] Heterogeneous resistance mechanisms in an EGFR exon 19-mutated non-small cell lung cancer patient treated with erlotinib: Persistent FGFR3-mutation, localized transformation to EGFR-mutated SCLC, and acquired T790M EGFR-mutation
    Santoni-Rugiu, Eric
    Grauslund, Morten
    Melchior, Linea C.
    Costa, Junia C.
    Sorensen, Jens B.
    Urbanska, Edyta M.
    LUNG CANCER, 2017, 113 : 14 - 17
  • [4] Concomitant Plasma-Genotyped T790M Positivity and Small Cell Carcinoma Transformation in EGFR-Mutated NSCLC
    Bhuniya, S.
    Mohapatra, P.
    Mishra, P.
    Patra, S.
    Panigrahi, M.
    Pradhan, G.
    Sahoo, S.
    Samal, S.
    JOURNAL OF THORACIC ONCOLOGY, 2018, 13 (10) : S869 - S869
  • [5] Liquid Biopsy in EGFR-Mutated Advanced NSCLC from T790M to MET Amplification: Clinical Implications and Possibilities in the Resistance Setting
    Della Gravara, Luigi
    Battiloro, Ciro
    Avellino, Aniello
    Caputo, Francesca
    D'Aniello, Carmine
    Rocco, Danilo
    JOURNAL OF MOLECULAR PATHOLOGY, 2023, 4 (02): : 81 - 88
  • [6] Simultaneous Acquisition of T790M Mutation and SCLC Transformation during Targeted Therapy in EGFR-Mutated Lung Adenocarcinoma: A Rare Case Report
    Yazaki, Tatsuya
    Kimoto, Masanobu
    Minagawa, Ayumi
    Maruno, Takashi
    Yamanaka, Miwa
    Sonehara, Kei
    Hama, Mineyuki
    Nakamura, Toshitsugu
    Kanda, Shintaro
    Hanaoka, Masayuki
    Hachiya, Tsutomu
    AMERICAN JOURNAL OF CASE REPORTS, 2024, 25
  • [7] Alternating Osimertinib and Gefitinib as Second-Line Treatment for EGFR-Mutated NSCLC Harbouring a T790M Resistance Mutation (OSCILLATE)
    Solomon, B.
    Mersiades, A.
    Brown, C.
    Dawson, S.
    Wong, S.
    Tan, L.
    Yip, S.
    Cheung, Y.
    Jurkovic, H.
    Walker, M.
    Kao, S.
    Lee, C. K.
    Newnham, G.
    O'Byrne, K.
    Parakh, S.
    Jasas, K.
    Bray, V.
    Stockler, M.
    John, T.
    Pavlakis, N.
    JOURNAL OF THORACIC ONCOLOGY, 2021, 16 (03) : S615 - S616
  • [8] Squamous Cell Carcinoma "Transformation" Concurrent with Secondary T790M Mutation in Resistant EGFR-Mutated Adenocarcinomas
    Jukna, Agita
    Montanari, Gloria
    Mengoli, Maria Cecilia
    Cavazza, Alberto
    Covi, Marisa
    Barbieri, Fausto
    Bertolini, Federica
    Rossi, Giulio
    JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (04) : E49 - E51
  • [9] Clinical implications of the T790M mutation in disease characteristics and treatment response in patients with EGFR-mutated NSCLC.
    Gaut, Daria
    Sim, Myung Shin
    Wolf, Brian R.
    Abarca, Phillip A.
    Carroll, James M.
    Goldman, Jonathan Wade
    Garon, Edward B.
    JOURNAL OF CLINICAL ONCOLOGY, 2017, 35
  • [10] Osimertinib Improves Overall Survival in Patients With EGFR-Mutated NSCLC With Leptomeningeal Metastases Regardless of T790M Mutational Status
    Lee, Jiyun
    Choi, Yoon La
    Han, Joungho
    Park, Sehhoon
    Jung, Hyun Ae
    Su, Jong-Mu
    Lee, Se-Hoon
    Ahn, Jin Seok
    Park, Keunchil
    Ahn, Myung-Ju
    JOURNAL OF THORACIC ONCOLOGY, 2020, 15 (11) : 1758 - 1766