Synthesis and Antitumor Activity of New Polysubstituted Thiophenes and 1,3,4-Thiadiazoles Incorporating 2,6-Pyridine Moieties

被引：14
|
作者：
Ali, Korany A. [1 ]
Abdalghfar, Heba S. [1 ]
Mahmoud, Khaled [2 ]
Ragab, Eman A. [3 ]
机构：
[1] Natl Res Ctr, Appl Organ Chem Dept, Cairo 12622, Egypt
[2] Natl Res Ctr, Dept Pharmacognosy, Cairo 12622, Egypt
[3] Cairo Univ, Dept Chem, Fac Sci, Cairo 12613, Egypt
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2013年 / 50卷 / 05期
关键词：
BIOLOGICAL EVALUATION; HETEROCYCLES; DERIVATIVES; THIAZOLE; PYRAZOLE;
D O I：
10.1002/jhet.1613
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The versatile multifunctional unreported pyridine-2,6-bis(2-cyano-N-phenyl-3-oxopropanethioamide) (3) was prepared starting from pyridine-2,6-bis-(3-oxopropanenitrile) (1). Several new series of polysubstituted thiophenes and 1,3,4-thiadiazoles incorporating 2,6-pyridine moiety were efficiently synthesized. The newly synthesized compounds were evaluated for their in vitro anticancer activity against human cancer cell lines: hepatocellular liver carcinoma (HEPG2) and Caucasian breast adenocarcinoma (MCF-7). Some of the newly synthesized compounds exhibited better activity than doxorubicin as a reference drug.
引用
收藏
页码：1157 / 1164
页数：8
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