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A novel chromogenic plasmin substrate Isoval-Phe-Lys:PNA hydrochloride: A mild approach to the synthesis of N-alpha-peptidyl-L-lysine p-nitroanilides
被引：3
|作者：
Wijkmans, JCHM
Nagel, A
Bloemhoff, W
机构：
[1] GORLAEUS LABS,LEIDEN INST CHEM,2300 RA LEIDEN,NETHERLANDS
[2] TNO,GAUBIUS LAB,PG,2301 CE LEIDEN,NETHERLANDS
来源：
关键词：
CF3-PyBOP;
chromogenic plasmin substrate;
p-nitroanilides;
N-trityl protection;
D O I：
10.1007/BF00126740
中图分类号：
Q5 [生物化学];
Q7 [分子生物学];
学科分类号：
071010 ;
081704 ;
摘要：
N-alpha-peptidyl-L-lysine p-nitroanilides may easily be prepared under mild conditions starting from commercially available H-Lys(Boc)-pNA (3) and N-alpha-tritylated amino acids using CF3-PyBOP (1) as condensating reagent. An illustration of this approach was given by the synthesis of the novel promising plasmin substrate isovaleryI-L-phenylalanyl-L-lysine p-nitroanilide hydrochloride (6).
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页码：107 / 112
页数：6
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