Mathematical Modeling of Hydrodynamics in Bioreactor by Means of CFD-Based Compartment Model

被引：11

作者：

Krychowska, Agnieszka ^{[1
]}

Kordas, Marian ^{[1
]}

Konopacki, Maciej ^{[1
]}

Grygorcewicz, Bartlomiej ^{[2
]}

Musik, Daniel ^{[1
,3
]}

Wojcik, Krzysztof ^{[1
,3
]}

Jedrzejczak-Silicka, Magdalena ^{[4
]}

Rakoczy, Rafal ^{[1
]}

机构：

[1] West Pomeranian Univ Technol Szczecin, Fac Chem Technol & Engn, Piastow Ave 42, PL-71065 Szczecin, Poland

[2] Pomeranian Med Univ, Dept Lab Med, Al Powstancow Wielkopolskich 72, PL-70111 Szczecin, Poland

[3] ESC Global Sp Zoo, Slone Sad 4F, PL-72002 Doluje, Poland

[4] West Pomeranian Univ Technol Szczecin, Fac Biotechnol & Anim Husb, Janickiego St 32, PL-71270 Szczecin, Poland

来源：

PROCESSES | 2020年 / 8卷 / 10期

关键词：

biochemical engineering; bioreactors; mathematical modeling; modeling; RESIDENCE TIME DISTRIBUTION; COMPUTATIONAL FLUID-DYNAMICS; REACTOR; DESIGN; MIXER;

D O I：

10.3390/pr8101301

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

This study presents the procedure of deriving a compartmental model (CM) based on an analysis obtained from the computational fluid dynamics (CFD) model of a bioreactor. The CM is composed of two parts, a structural (that takes into account the architecture of the mathematical model), and a parametric part (which contains the extrinsic parameters of the model). The CM is composed of the branches containing the set of perfectly mixed continuous stirred-tank reactors (CSTRs) in a configuration that matches the bioreactor's flow patterns. Therefore, this work's main objective was to develop a mathematical model that incorporated the flow field obtained by CFD technique. The proposed mathematical model was validated by means of the experimental data in the form of the residence time distribution (RTD) measurements.

引用

页码：1 / 12

页数：12

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