Mitomycin C-treated human-induced pluripotent stem cells as a safe delivery system of gold nanorods for targeted photothermal therapy of gastric cancer

被引：38
|
作者：
Yang, Meng [1 ,2 ]
Liu, Yanlei [1 ,2 ]
Hou, Wenxiu [1 ,2 ]
Zhi, Xiao [1 ]
Zhang, Chunlei [1 ]
Jiang, Xinquan [3 ]
Pan, Fei [1 ]
Yang, Yuming [1 ]
Ni, Jian [1 ]
Cui, Daxiang [1 ,2 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Engn Res Ctr Intelligent Diag & Treatmen, Sch Elect Informat & Elect Engn, Inst Nano Biomed & Engn,Natl Ctr Translat Med,Dep, Shanghai 200240, Peoples R China
[2] Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200240, Peoples R China
[3] Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 9, Dept Prosthodont, Shanghai 200011, Peoples R China
来源：
NANOSCALE | 2017年 / 9卷 / 01期
关键词：
PHASE-I; TRAFFICKING; GROWTH; GLIOMA; MODEL; FLOW;
D O I：
10.1039/c6nr06851k
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Human-induced pluripotent stem cells (iPS) possess an intrinsic tumor tropism ability. However, iPS cells are impeded in clinical applications of tumor therapy due to the formation of teratomas and their survival in normal organs such as the liver, lungs, spleen and kidneys. Mitomycin C (MMC) can overcome this limitation by suppressing iPS proliferation. Herein, we fabricated a safe delivery system of iPS cells treated with MMC loading with gold nanorods (AuNRs) for the targeted photothermal treatment of gastric cancer. Our results showed that the tumor cells were efficiently killed by the heat generated from the gold nanorods, and the iPS cells ultimately died due to the action of MMC seven days after the photothermal treatment. This suggested that pre-treated iPS cells with MMC can be used as a novel and safe approach for targeted tumor therapy. This paves the road for clinical translation in the future.
引用
收藏
页码：334 / 340
页数：7
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