Determination of zolpidem and its metabolites by chromatography-mass spectrometry

被引：6

作者：

Krylova, E. A. ^{[1
]}

Kataev, S. S. ^{[1
]}

Khomov, Yu. A. ^{[2
]}

机构：

[1] Perm Reg Bur Forens Med Examinat, Perm 614077, Russia

[2] Perm State Pharmaceut Acad, Perm 614081, Russia

来源：

JOURNAL OF ANALYTICAL CHEMISTRY | 2013年 / 68卷 / 08期

关键词：

zolpidem; metabolism; solid-phase extraction; gas chromatography; mass spectrometric detection;

D O I：

10.1134/S1061934813080066

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Conditions of the simultaneous isolation of various types of zolpidem metabolites from samples of real urine by solid-phase extraction have been optimized. Various derivatives of zolpidem hydroxy- and carboxy-metabolites were obtained; their mass-spectral and gas-chromatographic characteristics have been studied. The results ensure the reliable identification of zolpidem metabolites by gas chromatography-mass spectrometry for chemical toxicological and forensic investigations.

引用

页码：722 / 729

页数：8

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