Hippo-YAP signaling pathway: A new paradigm for cancer therapy

被引：78

作者：

Ma, Yanlei ^{[1
]}

Yang, Yongzhi ^{[1
]}

Wang, Feng ^{[1
]}

Wei, Qing ^{[2
]}

Qin, Huanlong ^{[1
]}

机构：

[1] Tongji Univ, Shanghai Peoples Hosp 10, Dept GI Surg, Shanghai 200072, Peoples R China

[2] Tongji Univ, Shanghai Peoples Hosp 10, Dept Pathol, Shanghai 200072, Peoples R China

来源：

INTERNATIONAL JOURNAL OF CANCER | 2015年 / 137卷 / 10期

基金：

中国国家自然科学基金;

关键词：

hippo; yap; cancer; therapy; YES-ASSOCIATED PROTEIN; HEPATOCELLULAR-CARCINOMA DEVELOPMENT; MEDIATES CONTACT INHIBITION; POLARITY DETERMINANT CRUMBS; LATS1; TUMOR-SUPPRESSOR; ORGAN SIZE CONTROL; PDZ-BINDING MOTIF; CELL-PROLIFERATION; TRANSCRIPTIONAL COACTIVATOR; ACTIN-BINDING;

D O I：

10.1002/ijc.29073

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In the past decades, the Hippo signaling pathway has been delineated and shown to play multiple roles in the control of organ size in both Drosophila and mammals. In mammals, the Hippo pathway is a kinase cascade leading from Mst1/2 to YAP and its paralog TAZ. Several studies have demonstrated that YAP/TAZ is a candidate oncogene and that other members of the Hippo pathway are tumor suppressive genes. The dysregulation of the Hippo pathway has been observed in a variety of cancers. This review chronicles the recent progress in elucidating the function of Hippo signaling in tumorigenesis and provide a rich source of potential targets for cancer therapy.

引用

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页码：2275 / 2286

页数：12

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