A first-in-class orally available HBV cccDNA destabilizer ccc_R08 achieved sustainable HBsAg and HBV DNA suppression in the HBV circle mouse model through elimination of cccDNA-like molecules in the mouse liver

被引:11
|
作者
Wang, Li [1 ]
Zhu, Qihui [1 ]
Zeng, Jing [1 ]
Yan, Zhipeng [1 ]
Feng, Andrew [1 ]
Young, John [2 ]
Gao, Lu [1 ]
机构
[1] Roche Innovat Ctr Shanghai, Shanghai, Peoples R China
[2] Roche Innovat Ctr Basel, Basel, Switzerland
关键词
D O I
10.1016/S0618-8278(19)30086-6
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
PS-074
引用
收藏
页码:E48 / E48
页数:1
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