The Autotaxin Inhibitor GLPG1690 Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice

被引：0
|
作者：
Murgo, A. [1 ]
Canciani, B. [2 ]
Fragni, D. [1 ]
Donetti, E. [2 ]
Civelli, M. [1 ]
Villetti, G. [1 ]
Miglietta, D. [1 ]
机构：
[1] Chiesi Farmaceut SpA, Corp Preclin R&D, Parma, Italy
[2] Univ Milan, Dept Biomed Sci Hlth, Milan, Italy
来源：
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE | 2019年 / 199卷
关键词：
D O I：
暂无
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
A5239
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Pharmacological Profile And Efficacy Of Glpg1690, A Novel Autotaxin Inhibitor For The treatment Of Idiopathic Pulmonary Fibrosis
    Van der Aar, E. M.
    Heckmann, B.
    Blanque, R.
    Desroy, N.
    Dupont, S.
    Cottereaux, C.
    Monjardet, A.
    Wakselman, E.
    Dirven, D.
    Christophe, T.
    Hrvacic, B.
    Ralic, J.
    Marsais, F.
    Brys, R.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [2] Population Pharmacokinetic and Pharmacodynamic Analysis of GLPG1690, an Autotaxin Inhibitor, in Healthy Volunteers and Patients with Idiopathic Pulmonary Fibrosis
    Amit Taneja
    Julie Desrivot
    Paul Matthias Diderichsen
    Roland Blanqué
    Lisa Allamasey
    Liesbeth Fagard
    Ann Fieuw
    Ellen Van der Aar
    Florence Namour
    Clinical Pharmacokinetics, 2019, 58 : 1175 - 1191
  • [3] Population Pharmacokinetic and Pharmacodynamic Analysis of GLPG1690, an Autotaxin Inhibitor, in Healthy Volunteers and Patients with Idiopathic Pulmonary Fibrosis
    Taneja, Amit
    Desrivot, Julie
    Diderichsen, Paul Matthias
    Blanque, Roland
    Allamasey, Lisa
    Fagard, Liesbeth
    Fieuw, Ann
    Van Der Aar, Ellen
    Namour, Florence
    CLINICAL PHARMACOKINETICS, 2019, 58 (09) : 1175 - 1191
  • [4] Discovery of GLPG1690: A first-in-class autotaxin inhibitor in clinical development for the treatment of idiopathic pulmonary fibrosis
    Desroy, Nicolas
    Joncour, Agnes
    Bock, Xavier
    Housseman, Christopher
    Peixoto, Christophe
    Bienvenu, Natacha
    Labeguere, Virginie
    Cherel, Laetitia
    Annoot, Denis
    Christophe, Thierry
    Conrath, Katja
    Triballeau, Nicolas
    Mollat, Patrick
    Wohlkonig, Alexandre
    Blanque, Roland
    Cottereaux, Celine
    Hrvacic, Boska
    Borgonovi, Monica
    Monjardet, Alain
    Van der Aar, Ellen
    Brys, Reginald
    Heckmann, Bertrand
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [5] Favorable Human Safety, Pharmacokinetics And Pharmacodynamics Of The Autotaxin Inhibitor Glpg1690, A Potential New Treatment In Idiopathic Pulmonary Fibrosis
    Van der Aar, E. M.
    Fagard, L.
    Desrivot, J.
    Dupont, S.
    Heckmann, B.
    Blanque, R.
    Gheyle, L.
    Ralic, J.
    Vanhoutte, F.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [6] Strong reversal of the lung fibrosis disease signature by autotaxin inhibitor GLPG1690 in a mouse model for IPF
    Ongenaert, Mate
    Dupont, Sonia
    Blanque, Roland
    Brys, Reginald
    van der Aar, Ellen
    Heckmann, Bertrand
    EUROPEAN RESPIRATORY JOURNAL, 2016, 48
  • [7] Simvastatin attenuates bleomycin-induced pulmonary fibrosis in mice
    OU Xue-mei
    Department of Respiratory Medicine
    中华医学杂志（英文版）, 2008, (18) : 1821 - 1829
  • [8] Danaparoid Attenuates Bleomycin-Induced Pulmonary Fibrosis In Mice
    Wang, X.
    Tanino, Y.
    Nikaido, T.
    Kikuchi, M.
    Sato, Y.
    Fukuhara, N.
    Misa, K.
    Togawa, R.
    Suzuki, Y.
    Uematsu, M.
    Fukuhara, A.
    Sato, S.
    Saito, J.
    Yokouchi, H.
    Munakata, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [9] Vagotomy attenuates bleomycin-induced pulmonary fibrosis in mice
    Song, Nana
    Liu, Jun
    Shaheen, Saad
    Du, Lei
    Proctor, Mary
    Roman, Jesse
    Yu, Jerry
    SCIENTIFIC REPORTS, 2015, 5
  • [10] Imrecoxib attenuates bleomycin-induced pulmonary fibrosis in mice
    Miao, Yang
    Yang, Yue
    Li, Xiaohe
    Meng, Lingxin
    Mao, Jiahe
    Zhang, Jianwei
    Gao, Jingjing
    Yang, Cheng
    Gu, Xiaoting
    Zhou, Honggang
    Zhang, Yanping
    HELIYON, 2023, 9 (11)
12345