Synthesis of 1,4-Dicarbonyl Compounds by Visible-Light-Mediated Cross-Coupling Reactions of α-Chlorocarbonyls and Enol Acetates

Herein, we report a protocol for visible-light-mediated radical coupling reactions of alpha-chloroketones and enol acetates to afford 1,4-dicarbonyl compounds, which are important precursors and intermediates in organic synthesis. The reaction involves photoredox-catalyzed activation of the alpha-chloroketone upon photoelectron transfer, carbon-chlorine bond cleavage, and coupling of the resulting radical with the carbon-carbon double bond of the enol acetate. This mild protocol has a wide substrate scope and moderate to good yields.