Case report: Neonatal delayed peristalsis after in-utero exposure to clozapine

被引:5
|
作者
Moreno-Bruna, M. -D. [1 ]
de Montgolfier, I. [2 ]
Chabaud, M. [3 ]
Dommergues, M. [4 ]
机构
[1] Hop Lariboisiere, AP HP, Grp Hosp Univ St Louis Lariboisiere Fernand Widal, Unite Neonatol, F-75475 Paris 10, France
[2] Hop Trousseau, AP HP, Grp Hosp HUEP, Serv Neonatol, F-75571 Paris 12, France
[3] Hop Trousseau, AP HP, Grp Hosp HUEP, Serv Chirurg Viscerale Pediatr & Neonatale, F-75571 Paris 12, France
[4] AP HP, Grp Hosp Pitie Salpetriere Charles Foix, Serv Gynecol Obstetr, F-75651 Paris 13, France
来源
ARCHIVES DE PEDIATRIE | 2012年 / 19卷 / 09期
关键词
NEWBORN; WEIGHT; DRUGS; WOMEN;
D O I
10.1016/j.arcped.2012.06.019
中图分类号
R72 [儿科学];
学科分类号
100202 ;
摘要
Schizophrenic women can now complete a pregnancy successfully, mostly due to psychiatric stabilization obtained with neuroleptic treatment. Side effects of classic neuroleptics are largely described in adults. On the other hand, effects of atypical neuroleptics, which are indicated when there is chronic severe schizophrenia with resistance or major intolerance to classic neuroleptics, are little known in newborn infants. We report the case of a hypertrophic fullterm newborn whose mother received clozapine treatment alone with decreasing posology during the course of pregnancy. On his 2nd day of life, this newborn infant presented delayed peristalsis that required hospitalization in the digestive surgery department for more than 2 weeks. We assume that the anti-cholinergic effect of this molecule associated with a substantial plasmatic concentration and a possible increased half-life elimination were involved. Neonatal delayed peristalsis associated with clozapine treatment alone during pregnancy is poorly described in the medical literature. We only found one report on plasmatic concentrations of clozapine and its metabolite in a newborn, published in 1994. Close digestive monitoring is needed in the first days of life after in-utero exposure to clozapine and we believe that the question of a delayed initiation of enteral feeding after meconium elimination and in the absence of abdominal distension is debatable. (c) 2012 Elsevier Masson SAS. All rights reserved.
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页码:913 / 916
页数:4
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