To identify risk factors for post-partum hemorrhage (PPH) following vacuum assisted vaginal delivery (VAVD). A retrospective study of all women with singleton pregnancies who underwent VAVD in a tertiary hospital (2012-2014). PPH was defined as any of the following: ae500 ml estimated blood loss, hemoglobin drop ae3 g/dl (difference between pre- and post-VAVD hemoglobin levels) or the need for blood products transfusion. Characteristics of women with PPH following VAVD were compared to those of women with no PPH following VAVD. Of 1,154 VAVDs, 295 (25.6 %) had PPH. Women in the PPH group were more often nulliparous (83.1 vs. 70.5 %, p = 0.001) and had higher rate of hypertensive disorders (4.4 vs. 1.4 %, p = 0.001). The rate of episiotomy (87.8 vs. 81.6 %, p = 0.01) was higher in the PPH group. In multivariate analysis, risk factors for PPH were (Odds Ratio, 95 % Confidence Interval) hypertensive disorders (2.40, 1.03-5.58, p = 0.04), induction of labor (1.42, 1.01-2.10, p = 0.04) and longer second (1.003, 1.001-1.006, p = 0.03) and 3rd (1.02, 1.01-1.04, p = 0.004) stages of labor. Risk factors for PPH following VAVD can be identified and should be taken into consideration at the immediate post-partum period.