The chameleon of retaining glycoside hydrolases and retaining glycosyl transferases: The catalytic nucleophile

被引：13
|
作者：
Stick, RV [1 ]
Watts, AG [1 ]
机构：
[1] Univ Western Australia, Dept Chem, Crawley, WA 6009, Australia
来源：
MONATSHEFTE FUR CHEMIE | 2002年 / 133卷 / 04期
关键词：
glycoside hydrolases; glycosyl transferases; 2-deoxy-2-fluoro hexopyranoses;
D O I：
10.1007/s007060200027
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
This paper addresses the existence and role of a catalytic nucleophile in retaining glycoside hydrolases and retaining glycosyl transferases. Although the former has now been established beyond doubt, such is not the case with the latter. We report reliable procedures for the synthesis of various 2-deoxy-2-fluoro glycosyl nucleoside diphosphates, useful donor analogues for the study of the mechanism of action of retaining glycosyl transferases.
引用
收藏
页码：541 / 554
页数：14
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