Ligand-Free Copper-Catalyzed One-Pot Synthesis of Indole-2-carboxylic Esters

被引：15
|
作者：
Zhu, Zhiqiang [1 ]
Yuan, Jiangjun [2 ,3 ]
Zhou, Yirong [2 ,3 ]
Qin, Yang [2 ,3 ]
Xu, Jingshi [1 ]
Peng, Yiyuan [1 ,2 ,3 ]
机构：
[1] Jiangxi Normal Univ, Jiangxi Prov & Coll Chem, Key Lab Green Chem, Nanchang 330022, Jiangxi, Peoples R China
[2] Jiangxi Normal Univ, Minist Educ, Key Lab Small Fuct Organ Mol, Nanchang 330022, Jiangxi, Peoples R China
[3] Jiangxi Normal Univ, Coll Life Sci, Nanchang 330022, Jiangxi, Peoples R China
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Synthetic methods; Domino reactions; Nitrogen heterocycles; Copper; SIMPLE INDOLE ALKALOIDS; SOLID-PHASE SYNTHESIS; C-H BONDS; NATURAL-PRODUCTS; N-ARYLATION; AMINATION REACTIONS; EFFICIENT SYNTHESIS; COUPLING REACTIONS; CASCADE SYNTHESIS; FACILE SYNTHESIS;
D O I：
10.1002/ejoc.201301607
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, efficient, and facile synthetic route for the preparation of indole-2-carboxylic esters was described. The cascade reactions of 2-bromobenzaldehyde and glycine ester hydrochloride were promoted by Cu2O and a base to provide the corresponding products in good yields. Commercially available, inexpensive substrates and reagents were employed under mild reaction conditions in this one-pot operation, which is complementary to existing methods for access to 2-substituted indoles.
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页码：511 / 514
页数：4
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