Depletion of enteroantigen-activated CD4+ T cells: effects on proliferation and pathogenicity

被引:1
|
作者
Belmaati, Mohammed-Samir [1 ]
Claesson, Mogens H. [1 ]
机构
[1] Univ Copenhagen, Panum Inst, Dept Immunol & Microbiol, Fac Hlth Sci, DK-2200 Copenhagen, Denmark
关键词
colitis; SCID; T cells; VERSUS-HOST DISEASE; ENTERIC BACTERIA; SCID MICE; LYMPHOCYTES; REACTIVITY; MICROBIOTA; COLITIS; CD25;
D O I
10.1093/intimm/dxv039
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Naive CD4(+) T cells depleted of natural T-reg (CD25(+)) cells proliferate extensively when exposed to a fecal extract [enteroantigen (eAg)] pulsed on antigen-presenting cells (APC). When transplanted into SCID recipient mice, the CD25-depleted T cells induce a chronic colitis with a lethal course. We observed here that if T cells, pre-activated for 48h by eAg from BALB/c or SCID mice, are removed and then reexposed to either of the two sources of antigen, these T cells have completely lost their anti-eAg proliferative capacity in vitro. This observation indicates that eAgs derived from Balb/c and SCID mice are recognized by similar subsets of T cells. However, when transferred into SCID mice, eAg-activation-depleted T cells are still capable of inducing a severe colitis fully comparable with the disease induced by naive CD4(+) T cells.
引用
收藏
页码:419 / 424
页数:6
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