Inhibition of YAP activation induces cell senescence and autophagy while blocking cell proliferation in cholangiocarcinoma (CCA)

被引:0
|
作者
Cadamuro, M. [1 ,2 ,3 ]
Casati, G. [1 ]
Stecca, T. [4 ]
Brivio, S. [1 ]
Milani, C. [1 ]
Mariotti, V. [3 ]
Kaffe, E. [5 ]
Spirli, C. [2 ,5 ]
Amenduni, M. [5 ]
Fiorotto, R. [2 ,5 ]
Cillo, U. [6 ]
Maria, G. [7 ]
Fabris, L. [2 ,3 ,5 ]
Strazzabosco, M. [1 ,2 ,5 ]
机构
[1] Univ Milano Bicocca, Sch Med & Surg, Monza, Italy
[2] Univ Milano Bicocca, Int Ctr Digest Hlth, Monza, Italy
[3] Univ Padua, Dept Mol Med, Padua, Italy
[4] Univ Padua, Dept Surg Oncol & Gastroenterol, Padua, Italy
[5] Yale Univ, Sect Digest Dis, New Haven, CT USA
[6] Univ Padua, Liver Transplant & HBP Surg Unit, Padua, Italy
[7] Univ Padua, Dept Med, Padua, Italy
关键词
D O I
10.1016/S0168-8278(18)31604-0
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
SAT-151
引用
收藏
页码:S673 / S673
页数:1
相关论文
共 50 条
  • [1] Targeting YAP in Cholangiocarcinoma (CCA) induces cell senescence while blocking cell proliferation
    Cadamuro, Massimiliano
    Brivio, Simone
    Stecca, Tommaso
    Mariotti, Valeria
    Spirli, Carlo
    Fiorotto, Romina
    Casati, Giacomo
    Pellarin, Eleonora
    Cillo, Umberto
    Guido, Maria
    Fabris, Luca
    Strazzabosco, Mario
    HEPATOLOGY, 2017, 66 : 933A - 933A
  • [2] Phenformin inhibits cell proliferation and induces cell apoptosis and autophagy in cholangiocarcinoma
    Hu, Shuyang
    Ouyang, Qing
    Cheng, Qingbao
    Wang, Jinghan
    Feng, Feiling
    Qiao, Liang
    Gan, Wei
    Shi, Yang
    Wu, Demin
    Jiang, Xiaoqing
    MOLECULAR MEDICINE REPORTS, 2018, 17 (04) : 6028 - 6032
  • [3] Inhibition of Wnt signaling induces cell apoptosis and suppresses cell proliferation in cholangiocarcinoma cells
    Zhang, Kun-Song
    Zhou, Qi
    Wang, Ya-Feng
    Liang, Li-Jian
    ONCOLOGY REPORTS, 2013, 30 (03) : 1430 - 1438
  • [4] Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
    Pavel, Mariana
    Renna, Maurizio
    Park, So Jung
    Menzies, Fiona M.
    Ricketts, Thomas
    Fullgrabe, Jens
    Ashkenazi, Avraham
    Frake, Rebecca A.
    Lombarte, Alejandro Carnicer
    Bento, Carla F.
    Franze, Kristian
    Rubinsztein, David C.
    NATURE COMMUNICATIONS, 2018, 9
  • [5] Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis
    Mariana Pavel
    Maurizio Renna
    So Jung Park
    Fiona M. Menzies
    Thomas Ricketts
    Jens Füllgrabe
    Avraham Ashkenazi
    Rebecca A. Frake
    Alejandro Carnicer Lombarte
    Carla F. Bento
    Kristian Franze
    David C. Rubinsztein
    Nature Communications, 9
  • [6] Cannabidiol suppresses proliferation and induces cell death, autophagy and senescence in human cholangiocarcinoma cells via the PI3K/AKT/ mTOR pathway
    Pongking, Thatsanapong
    Intuyod, Kitti
    Thongpon, Phonpilas
    Thanan, Raynoo
    Sitthirach, Chutima
    Chaidee, Apisit
    Kongsintaweesuk, Suppakrit
    Klungsaeng, Sirinapha
    Hongsrichan, Nuttanan
    Sakonsinsiri, Chadamas
    Vaeteewoottacharn, Kulthida
    Kanokmedhakul, Somdej
    Pinlaor, Somchai
    Pinlaor, Porntip
    JOURNAL OF TRADITIONAL AND COMPLEMENTARY MEDICINE, 2024, 14 (06): : 622 - 634
  • [7] Prodigiosin inhibits cholangiocarcinoma cell proliferation and induces apoptosis via suppressing SNAREs-dependent autophagy
    Zheng, Dijie
    Chen, Shiyu
    Cai, Kun
    Lei, Linhan
    Wu, Chunchen
    Sun, Chengyi
    Deng, Yazhu
    Yu, Chao
    CANCER CELL INTERNATIONAL, 2021, 21 (01)
  • [8] Prodigiosin inhibits cholangiocarcinoma cell proliferation and induces apoptosis via suppressing SNAREs-dependent autophagy
    Dijie Zheng
    Shiyu Chen
    Kun Cai
    Linhan Lei
    Chunchen Wu
    Chengyi Sun
    Yazhu Deng
    Chao Yu
    Cancer Cell International, 21
  • [9] Gallotannin induces senescence and autophagy leading to cell death via SIRT1 inhibition and AMPK activation in hepatocellular carcinoma cells
    Kwon, Hee Young
    Kim, Sung-hoon
    CANCER RESEARCH, 2016, 76
  • [10] Histone Deacetylase Inhibition and Autophagy Modulation Induces a Synergistic Antiproliferative Effect and Cell Death in Cholangiocarcinoma Cells
    Yenigul, Munevver
    Akcok, Emel Basak Gencer
    ACS OMEGA, 2023, 8 (24): : 21755 - 21768