High throughput one pot synthesis of 2-methylquinolines

被引：23
|
作者：
Chandrashekarappa, Kiran Kumar H. [1 ]
Mahadevan, Kittappa M. [1 ]
Manjappa, Kiran B. [2 ]
机构：
[1] Kuvempu Univ, Dept Post Grad Studies & Res Chem, Sch Chem Sci, Shankaraghatta 577451, Karnataka, India
[2] Natl Taiwan Univ Sci & Technol, Taipei 10607, Taiwan
来源：
TETRAHEDRON LETTERS | 2013年 / 54卷 / 11期
关键词：
2-Methylquinolines; Acetic acid; Ethy vinyl ether; aza-Diels-Alder reaction; Aniline; DIELS-ALDER REACTIONS; EFFICIENT SYNTHESIS; ACID; QUINOLINES;
D O I：
10.1016/j.tetlet.2012.12.094
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various 2-methylquinolines have been successfully synthesized by using anilines and ethyl vinyl ether in 1:3 mole ratios in the presence of acetic acid. Stirring at rt for 3-4 h followed by reflux for 3.5-4 h resulted in the corresponding 2-methylquinolines in good yield. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1368 / 1370
页数：3
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