Cars are increasingly equipped with functions that protect drivers from crashes. Forward Collision Warning and Brake Support combined with Adaptive Cruise Control (CWB+ACC) are collision-avoidance features available in modern cars. Previous real-world evaluations have reported on the crash-avoidance performance of these technologies. The objective of this study was to evaluate the safety effect of CWB+ACC in terms of crashes mitigated by reduced impact speed, as well as crashes avoided. The typical conflict situation addressed by the systems is a rear-end frontal collision, i.e. a collision with a vehicle in front of the subject car that is positioned in, or traveling along, the same path. Car-to-pedestrian and car-to-cyclist crashes are also addressed by these systems. For CWB+ACC cars, rear-end frontal collisions were reduced by 37%. A clear mitigating effect was found for different crash-severity levels, and the average number of spare parts used was reduced for CWB+ACC cars. No significant reduction of injured occupants was found for CWB+ACC cars (in striking or struck vehicles). Although an extensive dataset was used for the analysis, there were not enough car-to-pedestrian or car-tocyclist crashes available to obtain a statistically significant analysis of these events.