Breast vibro-acoustography: initial results show promise

被引:24
|
作者
Alizad, Azra [1 ,2 ]
Whaley, Dana H. [3 ]
Urban, Matthew W. [1 ]
Carter, Rickey E. [4 ]
Kinnick, Randall R. [1 ]
Greenleaf, James F. [1 ]
Fatemi, Mostafa [1 ]
机构
[1] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA
[2] Mayo Clin, Dept Internal Med, Rochester, MN 55905 USA
[3] Mayo Clin, Dept Radiol, Rochester, MN 55905 USA
[4] Mayo Clin, Div Biomed Stat & Informat, Rochester, MN 55905 USA
关键词
acoustic imaging; breast lesions; radiation force breast imaging; ultrasound; vibro-acoustography; ULTRASOUND ELASTOGRAPHY; RADIATION FORCE; MR ELASTOGRAPHY; LESIONS; CANCER; MAMMOGRAPHY; TISSUE; US; PERFORMANCE; ARTERIES;
D O I
10.1186/bcr3323
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Introduction: Vibro-acoustography (VA) is a recently developed imaging modality that is sensitive to the dynamic characteristics of tissue. It detects low-frequency harmonic vibrations in tissue that are induced by the radiation force of ultrasound. Here, we have investigated applications of VA for in vivo breast imaging. Methods: A recently developed combined mammography-VA system for in vivo breast imaging was tested on female volunteers, aged 25 years or older, with suspected breast lesions on their clinical examination. After mammography, a set of VA scans was acquired by the experimental device. In a masked assessment, VA images were evaluated independently by 3 reviewers who identified mass lesions and calcifications. The diagnostic accuracy of this imaging method was determined by comparing the reviewers' responses with clinical data. Results: We collected images from 57 participants: 7 were used for training and 48 for evaluation of diagnostic accuracy (images from 2 participants were excluded because of unexpected imaging artifacts). In total, 16 malignant and 32 benign lesions were examined. Specificity for diagnostic accuracy was 94% or higher for all 3 reviewers, but sensitivity varied (69% to 100%). All reviewers were able to detect 97% of masses, but sensitivity for detection of calcification was lower (<= 72% for all reviewers). Conclusions: VA can be used to detect various breast abnormalities, including calcifications and benign and malignant masses, with relatively high specificity. VA technology may lead to a new clinical tool for breast imaging applications.
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页数:10
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