A new intronic polymorphism in the C7 gene 36 bp from the common expressed C7 M/N polymorphism

被引：14
|
作者：
Fernie, BA [1 ]
Wurzner, R [1 ]
Orren, A [1 ]
Hobart, M [1 ]
机构：
[1] UNIV CAMBRIDGE,CTR MRC,MOLEC IMMUNOPATHOL UNIT,CAMBRIDGE CB2 2QH,ENGLAND
来源：
ANNALS OF HUMAN GENETICS | 1996年 / 60卷
关键词：
D O I：
10.1111/j.1469-1809.1996.tb01187.x
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
We report a new polymorphism in the complement C7 gene that results from an A-C transversion in intron 12, 27 bp upstream of exon 13 (C712.-27) and 36 bp upstream of the point mutation that underlies the C7 M/N antigenic polymorphism. The C7 12.-27 polymorphism subdivides C7 M haplotypes, but not C7 hi. It also sheds light on the evolution of the various types of deficiency genes at the adjacent CB locus.
引用
收藏
页码：179 / 182
页数：4
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