Cytokine production by monocytes, NK cells, and lymphocytes is different in preeclamptic patients as compared with normal pregnant women

被引：26
|
作者：
van Nieuwenhoven, Angelique L. Veenstra [3 ]
Moes, Henk [1 ,2 ]
Heineman, Maas Jan [3 ]
Santema, Job
Faas, Marijke M. [1 ,2 ]
机构：
[1] Univ Med Ctr Groningen, Dept Pathol & Lab Med, Div Med Biol, NL-9713 GZ Groningen, Netherlands
[2] Univ Groningen, NL-9700 AB Groningen, Netherlands
[3] Univ Med Ctr Groningen, Dept Obstet & Gynecol, NL-9713 GZ Groningen, Netherlands
来源：
HYPERTENSION IN PREGNANCY | 2008年 / 27卷 / 03期
关键词：
preeclampsia; cytokines; monocytes; lymphocytes; NK cells;
D O I：
10.1080/10641950701885006
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objective. To measure cytokine production in ex vivo stimulated leukocyte populations of women with normal pregnancy and those with preeclampsia. Methods. Whole blood from preeclamptic and normal pregnant women was stimulated with LPS or PMA/Ca-ionophore. The percentages of IFN and IL-2, 4, and 10 producing lymphocytes and NK cells and the percentages of TNF, IL-1, and IL-12 producing monocytes were measured by flowcytometry. Results. In women with preeclampsia, there was a significantly increased percentage IL-4 producing cytotoxic T cells. Also, a significant decreased percentage IL-2 producing T helper cells and IL-12 producing monocytes was seen as compared with normal pregnancy. Conclusion. Th1 cytokine production of lymphocytes and monocytes appears to be decreased in our group of preeclamptic patients compared with normal pregnant women.
引用
收藏
页码：207 / 224
页数：18
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