Understanding the Formation of Deep Eutectic Solvents: Betaine as a Universal Hydrogen Bond Acceptor

被引：88

作者：

Abranches, Dinis O. ^{[1
]}

Silva, Liliana P. ^{[1
]}

Martins, Monia A. R. ^{[1
]}

Pinho, Simao P. ^{[2
]}

Coutinho, Joao A. P. ^{[1
]}

机构：

[1] Univ Aveiro, Aveiro Inst Mat, Dept Chem, CICECO, P-3810193 Aveiro, Portugal

[2] Inst Politecn Braganca, Ctr Invest Montanha CIMO, Campus Santa Apolonia, P-5300253 Braganca, Portugal

来源：

CHEMSUSCHEM | 2020年 / 13卷 / 18期

关键词：

green chemistry; natural deep eutectic solvents; non-ideality; trimethylglycine; zwitterions; CHOLINE CHLORIDE; CARBOXYLIC-ACIDS; EXTRACTION; MEDIA;

D O I：

10.1002/cssc.202001331

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The mechanism of formation of betaine-based deep eutectic solvents (DES) is presented for the first time. Due to its polarity unbalance, it was found that betaine displays strong negative deviations from ideality when mixed with a variety of different organic substances. These results pave the way for a comprehensive design of novel deep eutectic solvents. A connection to biologically relevant systems was made using betaine (osmolyte) and urea (protein denaturant), showing that these two compounds formed a DES, the molecular interactions of which were greatly enhanced in the presence of water.

引用

页码：4916 / 4921

页数：6

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