Synthesis, spectroscopic characterization and structural investigations of new adduct compound of carbazole with picric acid: DNA binding and antimicrobial studies

被引：54
|
作者：
Saravanabhavan, Munusamy [1 ]
Sathya, Krishnan [1 ]
Puranik, Vedavati G. [2 ]
Sekar, Marimuthu [1 ]
机构：
[1] Sri Ramakrishna Mission Vidyalaya Coll Arts & Sci, Postgrad & Res Dept Chem, Coimbatore 641020, Tamil Nadu, India
[2] Natl Chem Lab, Ctr Mat Characterisat, Pune 411008, Maharashtra, India
来源：
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2014年 / 118卷
关键词：
CP adduct; TG-DTA; Single crystal XRD; Antimicrobial activity and DNA-interaction; (4-NITROPHENYL)ACETIC ACID; ELECTRICAL CONDUCTANCE; CRYSTAL-STRUCTURES; PICRATE; GROWTH; COCRYSTALS; COMPLEXES; ALKALOIDS;
D O I：
10.1016/j.saa.2013.08.115
中图分类号：
O433 [光谱学];
学科分类号：
0703 ; 070302 ;
摘要：
Carbazole picrate (CP), a new organic compound has been synthesized, characterized by various analytical and spectroscopic technique such as FT-IR, UV-Vis, H-1 and C-13 NMR spectroscopy. An orthorhombic geometry was proposed based on single crystal XRD study. The thermal stability of the crystal was studied by using thermo-gravimetric and differential thermal analyses and found that it was stable up to 170 degrees C. Further, the newly synthesized title compound was tested for its in vitro antibacterial and antifungal activity against various bacterial and fungal species. Also, the compound was tested for its binding activity with Calf thymus (CT) DNA and the results show a considerable interaction between CP and CT-DNA. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码：399 / 406
页数：8
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