Linezolid for treatment of subdural empyema due to Streptococcus: case reports

被引：5
|
作者：
Lefebvre, Laurent [1 ]
Metellus, Philippe [2 ]
Dufour, Henry [2 ]
Bruder, Nicolas [1 ]
机构：
[1] Univ Aix Marseille 2, CHU Timone, Dept Anesthesiol & Intens Care, Marseille, France
[2] Univ Aix Marseille 2, CHU Timone, Dept Neurosurg, Marseille, France
来源：
SURGICAL NEUROLOGY | 2009年 / 71卷 / 01期
关键词：
Subdural empyema; Linezolid; Streptococcus; Sepsis; Neurosurgical; NERVOUS-SYSTEM INFECTIONS; MENINGITIS; VANCOMYCIN;
D O I：
10.1016/j.surneu.2007.06.083
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Background: Recurring subdural empyema despite adequate surgical drainage and antibiotic treatment is still a life-threatening disease. This is mainly due to poor diffusion of the antibiotic into the subdural space. Case Description: We report 2 cases of recurring subdural empyema due to Streptococcus. after repeat surgery and high-dose antibiotic treatment including beta-lactamines and vancomycin. Both patients showed marked clinical and radiologic improvement after introduction of linezolid. There was no drug-related adverse effect despite 36 and 90 days of treatment. Conclusion: Off-label use of linezolid for treatment Of subdural empyema due to gram-positive bacteria should be considered after failure of conventional antibiotic treatment. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：89 / 91
页数：3
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