Genetic polymorphisms of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro and the risk of cervical cancer in Japanese

被引：47
|
作者：
Niwa, Y
Hamajima, N
Atsuta, Y
Yamamoto, K
Tamakoshi, A
Saito, T
Hirose, K
Nakanishi, T
Nawa, A
Kuzuya, K
Tajima, K
机构：
[1] Nagoya Univ, Grad Sch Med, Dept Prevent Med Biostat & Med Decis Making, Showa Ku, Nagoya, Aichi 4668550, Japan
[2] Aichi Canc Ctr, Res Inst, Dept Epidemiol & Prevent, Chikusa Ku, Nagoya, Aichi 4648681, Japan
[3] Aichi Canc Ctr Hosp, Dept Gynecol, Chikusa Ku, Nagoya, Aichi 4648681, Japan
来源：
CANCER LETTERS | 2004年 / 205卷 / 01期
关键词：
p73 two linked polymorphism; p53 Arg72Pro polymorphism; cervical cancer; polymerase chain reaction with confronting two-pair primers;
D O I：
10.1016/j.canlet.2003.11.014
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
To examine the possible association between cervical cancer and p73 G4C14-to-A4T14 in exon 2 and p53 Arg72Pro polymorphisms, an incident case-control study was conducted in Japanese. The cases were 112 cervical cancer patients. Controls were 320 healthy women and 122 non-cancer female outpatients. Risk estimation for each genotype by an unconditional logistic model demonstrated a possible association between the p73 A4T14 variant and the risk of cervical cancer in our Japanese population (OR = 1.57; 95%CI, 0.99-2.48, P = 0.053). There was no significant difference in the p53 Arg72Pro genotype frequency between the controls and cases. (C) 2003 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：55 / 60
页数：6
相关论文
共 50 条
  • [1] No associations of p73 G4C14-to-A4T14 at exon 2 and p53 Arg72Pro polymorphisms with the risk of digestive tract cancers in Japanese
    Hamajima, N
    Matsuo, K
    Suzuki, T
    Nakamura, T
    Matsuura, A
    Hatooka, S
    Shinoda, M
    Kodera, Y
    Yamamura, Y
    Hirai, T
    Kato, T
    Tajima, K
    CANCER LETTERS, 2002, 181 (01) : 81 - 85
  • [2] Association of p73 G4C14-to-A4T14 polymorphism at exon 2 and p53 Arg72Pro polymorphism with the risk of endometrial cancer in Japanese subjects
    Niwa, Y
    Hirose, K
    Matsuo, K
    Tajima, K
    Ikoma, Y
    Nakanishi, T
    Nawa, A
    Kuzuya, K
    Tamakoshi, A
    Hamajima, N
    CANCER LETTERS, 2005, 219 (02) : 183 - 190
  • [3] Polymorphisms of p53 Arg72Pro, p73 G4C14-to-A4T14 at exon 2 and p21 Ser31Arg and the risk of non-Hodgkin's lymphoma in Japanese
    Hishida, A
    Matsuo, K
    Tajima, K
    Ogura, M
    Kagami, Y
    Taji, H
    Morishima, Y
    Emi, N
    Naoe, T
    Hamajima, N
    LEUKEMIA & LYMPHOMA, 2004, 45 (05) : 957 - 964
  • [4] P73 G4C14-TO-A4T14 GENE POLYMORPHISM AND INTERACTION WITH P53 EXON 4 ARG72PRO ON CANCER SUSCEPTIBILITY: A META-ANALYSIS OF THE LITERATURE
    De Feo, E.
    Kamgaing, R.
    Benedetto, S.
    Matsuo, K.
    Li, G.
    Ricciardi, G.
    Boccia, S.
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 2009, 169 : S49 - S49
  • [5] p73 G4C14-to-A4T14 gene polymorphism and interaction with p53 exon 4 Arg72Pro on cancer susceptibility: a meta-analysis of the literature
    De Feo, Emma
    Simone, Benedetto
    Kamgaing, Rachel Simo
    Galli, Paola
    Hamajima, Nobuyuki
    Hu, Zhibin
    Li, Guojun
    Li, Yan
    Matsuo, Keitaro
    Park, Jae Yong
    Roychoudhury, Susanta
    Spitz, Margaret R.
    Wei, Qingyi
    Zhang, Jian-Hui
    Ricciardi, Walter
    Boccia, Stefania
    MUTAGENESIS, 2012, 27 (03) : 267 - 273
  • [6] Association ofp53 codon arg72pro andp73 G4C14-to-A4T14 at exon 2 genetic polymorphisms with the risk of japanese breast cancer
    Xin-En Huang
    Nobuyuki Hamajima
    Nobuyuki Katsuda
    Keitaro Matsuo
    Kaoru Hirose
    Mitsuhiro Mizutani
    Hiroji Iwata
    Shigeto Miura
    Jin Xiang
    Shinkan Tokudome
    Kazuo Tajima
    Breast Cancer, 2003, 10 (4) : 307 - 311
  • [7] p73 G4C14-to-A4T14 polymorphism and risk of lung cancer
    Li, GJ
    Wang, LE
    Chamberlain, RM
    Amos, CI
    Spitz, MR
    Wei, QY
    CANCER RESEARCH, 2004, 64 (19) : 6863 - 6866
  • [8] The Role of p73 G4C14-to-A4T14 Polymorphism in the Susceptibility to Cervical Cancer
    Craveiro, Rogeria
    Bravo, Isabel
    Catarino, Raquel
    Teixeira, Ana Luisa
    Sousa, Hugo
    Pereira, Deolinda
    Pereira, Helena
    Medeiros, Rui
    DNA AND CELL BIOLOGY, 2012, 31 (02) : 224 - 229
  • [9] Combined analysis of the association between p73 G4C14-to-A4T14 polymorphisms and cancer risk
    Wang, Lan
    Gao, Rui
    Yu, Long
    MOLECULAR BIOLOGY REPORTS, 2012, 39 (02) : 1731 - 1738
  • [10] Combined analysis of the association between p73 G4C14-to-A4T14 polymorphisms and cancer risk
    Lan Wang
    Rui Gao
    Long Yu
    Molecular Biology Reports, 2012, 39 : 1731 - 1738
12345