Microwave assisted solid phase synthesis of highly functionalized N-alkylated oligobenzamide α-helix mimetics

被引：36
|
作者：
Long, Kerya [1 ,2 ]
Edwards, Thomas A. [2 ,3 ]
Wilson, Andrew J. [1 ,2 ]
机构：
[1] Univ Leeds, Sch Chem, Leeds LS2 9JT, W Yorkshire, England
[2] Univ Leeds, Astbury Ctr Struct Mol Biol, Leeds LS2 9JT, W Yorkshire, England
[3] Univ Leeds, Sch Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2013年 / 21卷 / 14期
基金：
欧洲研究理事会;
关键词：
Aromatic oligoamide; Automated solid phase synthesis; Protein-protein interactions; Helix mimetic; PROTEIN-PROTEIN INTERACTIONS; P53-MDM2; INTERACTION; CANCER-THERAPY; AMINO-ACIDS; INHIBITORS; FOLDAMERS; DESIGN; SCAFFOLD; INTERFACE; MIMICRY;
D O I：
10.1016/j.bmc.2012.09.053
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Protein-protein interactions (PPIs) mediate cellular pathways and are implicated in numerous aberrant conditions. alpha-Helix mimetics-small molecules that reproduce the spatial projection of key residues from an alpha-helix involved in a PPI-are attractive generic templates for development of screening libraries, however library syntheses of alpha-helix mimetics with diverse functionality are less established. This manuscript describes the automated, microwave assisted solid phase synthesis based on one such scaffold; an N-allcylated oligobenzamide. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4034 / 4040
页数：7
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