T1 and extracellular volume mapping in the heart: estimation of error maps and the influence of noise on precision

被引:136
|
作者
Kellman, Peter [1 ]
Arai, Andrew E. [1 ]
Xue, Hui [1 ]
机构
[1] Natl Heart Lung & Blood Inst, Natl Inst Hlth, DHHS, Bethesda, MD 20892 USA
基金
美国国家卫生研究院;
关键词
T1; Map; Error; Precision; MOLLI; Extracellular; Diffuse Fibrosis; Cardiovascular Magnetic Resonance; SENSITIVE INVERSION-RECOVERY; DIFFUSE MYOCARDIAL FIBROSIS; MAGNETIC-RESONANCE; QUANTIFICATION; VALIDATION; INFARCTION; REGRESSION; MOLLI;
D O I
10.1186/1532-429X-15-56
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Quantitative measurements in the myocardium may be used to detect both focal and diffuse disease processes that result in an elevation of T1 and/or extracellular volume (ECV) fraction. Detection of abnormal myocardial tissue by these methods is affected by both the accuracy and precision. The sensitivity for detecting abnormal elevation of T1 and ECV is limited by the precision of T1 estimates which is a function of the number and timing of measurements along the T1-inversion recovery curve, the signal-to-noise ratio (SNR), the tissue T1, and the method of fitting. Methods: The standard deviation (SD) of T1 and ECV estimates are formulated and SD maps are calculated on a pixel-wise basis using the Modified Look-Locker Inversion recovery (MOLLI) method. SD estimates are validated by numerical simulation using Monte-Carlo analysis and with phantoms using repeated trials. SD estimates are provided for pre- and post-contrast optimized protocols for a range of T1s and SNRs. In-vivo examples are provide for normal, myocarditis, and HCM in human subjects. The formulation of SD maps was extended to R1 and ECV. Results: The measured myocardial SNR ranged from 23 to 43 across the heart using the specific T1-mapping protocol in this study. In this range of SNRs, the estimated SD for T1 was approximately 20-45 ms for pre-contrast myocardial T1 around 1000 ms, and was approximately 10-20 ms for post contrast T1 around 400 ms. The proposed estimate of SD was an unbiased estimate of the standard deviation of T1 validated by numerical simulation and had > 99% correlation with phantom measurements. The measured SD maps exhibited variation across the heart due to drop off in surface coil sensitivity as expected for the variation in SNR. Focal elevation in T1 and ECV was shown to have statistical significance on a pixel-wise basis for in-vivo examples. Conclusions: Pixel-wise estimates of T1 mapping errors have been formulated and validated, and the formulation has been extended to ECV. The ability to quantify the measurement error has potential to determine the statistical significance of subtle abnormalities that arise due to diffuse disease processes involving fibrosis and/or edema and is useful both as a confidence metric for overall quality, and in optimization and comparison of imaging protocols.
引用
收藏
页数:12
相关论文
共 50 条
  • [1] T1 and extracellular volume mapping in the heart: estimation of error maps and the influence of noise on precision
    Peter Kellman
    Andrew E Arai
    Hui Xue
    Journal of Cardiovascular Magnetic Resonance, 15
  • [2] T1 and extracellular volume fraction mapping in cardiac magnetic resonance: estimation of accuracy and precision of a novel algorithm
    Borrazzo, Cristian
    Pacilio, Massimiliano
    Galea, Nicola
    Preziosi, Enrico
    Carni, Marco
    Francone, Marco
    Catalano, Carlo
    Carbone, Iacopo
    PHYSICS IN MEDICINE AND BIOLOGY, 2019, 64 (04):
  • [3] Myocardial T1 and extracellular volume fraction mapping at 3 tesla
    Jason J Lee
    Songtao Liu
    Marcelo S Nacif
    Martin Ugander
    Jing Han
    Nadine Kawel
    Christopher T Sibley
    Peter Kellman
    Andrew E Arai
    David A Bluemke
    Journal of Cardiovascular Magnetic Resonance, 13
  • [4] Myocardial T1 and Extracellular Volume Fraction Mapping at 3 Tesla
    Lee, Jason J.
    Liu, Songtao
    Nacif, Marcelo S.
    Ugander, Martin
    Han, Jing
    Kawel, Nadine
    Sibley, Christopher T.
    Kellman, Peter
    Arai, Andrew E.
    Bluemke, David A.
    JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE, 2011, 13
  • [5] Assessing Myocardial Extracellular Volume by T1 Mapping to Distinguish Hypertrophic Cardiomyopathy From Athlete's Heart
    Swoboda, Peter P.
    McDiarmid, Adam K.
    Erhayiem, Bara
    Broadbent, David A.
    Dobson, Laura E.
    Garg, Pankaj
    Ferguson, Carrie
    Page, Stephen P.
    Greenwood, John P.
    Plein, Sven
    JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 67 (18) : 2189 - 2190
  • [6] Cardiac MRI T1 mapping and extracellular volume application in hypertrophic cardiomyopathy
    Ali, Nahla D.
    Behairy, Noha
    Kharabish, Ahmed
    Elmozy, Wesam
    Hegab, Ahmed Yahya
    Saraya, Samira
    EGYPTIAN JOURNAL OF RADIOLOGY AND NUCLEAR MEDICINE, 2021, 52 (01):
  • [7] Right Ventricular Extracellular Volume Fraction by Magnetic Resonance T1 Mapping in Pulmonary Hypertension and Heart Failure
    Bilchick, Kenneth C.
    Mehta, Bhairav B.
    Workman, Virginia
    Auger, Daniel
    Chen, Xiao
    Kennedy, Jamie
    Gay, Elizabeth
    Epstein, Frederick H.
    CIRCULATION, 2015, 132
  • [8] Prognostic Value of Liver T1 Mapping and Extracellular Volume in Dilated Cardiomyopathy
    Wang, Jiaqi
    Xu, Yuanwei
    Guo, Jiajun
    Li, Yangjie
    Chen, Yucheng
    CIRCULATION, 2022, 146
  • [9] Role of cardiac T1 mapping and extracellular volume in the assessment of myocardial infarction
    Garg, Pankaj
    Saunders, Laura C.
    Swift, Andrew J.
    Wild, Jim M.
    Plein, Sven
    ANATOLIAN JOURNAL OF CARDIOLOGY, 2018, 19 (06): : 404 - 411
  • [10] T1 Mapping and Extracellular Volume Fraction in Dilated Cardiomyopathy A Prognosis Study
    Li, Shuang
    Zhou, Di
    Sirajuddin, Arlene
    He, Jian
    Xu, Jing
    Zhuang, Baiyan
    Huang, Jinghan
    Yin, Gang
    Fan, Xiaohan
    Wu, Weichun
    Sun, Xiaoxin
    Zhao, Shihua
    Arai, Andrew E.
    Lu, Minjie
    JACC-CARDIOVASCULAR IMAGING, 2022, 15 (04) : 578 - 590