Organocatalytic Michael Addition of Aldehydes to Vinyl Sulfones: Enantioselective α-Alkylations of Aldehydes and Their Derivatives

被引：77
|
作者：
Zhu, Qiang [1 ]
Lu, Yixin [1 ]
机构：
[1] Natl Univ Singapore, Inst Life Sci, Dept Chem & Med Chem Program, Singapore 117543, Singapore
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 21期
关键词：
D O I：
10.1021/ol8019296
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Organocatalytic asymmetric Michael reaction of unmodified aldehydes to vinyl sulfones catalyzed by silylated biarylprolinol afforded the desired Michael products with exceptional enantioselectivity. The described enantioselective addition to vinyl sulfones, in combination with desulfonation, offers a unique, asymmetric entry to alpha-alkylated aldehydes and their derivatives.
引用
收藏
页码：4803 / 4806
页数：4
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